# The cartilage reading list

> Reading list — Renew Regenerative Med — The Renew Regenerative Med reading list: the rabbit cartilage experiment, AOD-9604's metabolic ancestry, oral tolerability and a later safety assessment.

**Reading list**

The joint experiment is the starting point. The older metabolic papers explain the ancestry; the human report and a later review change the scale of the question.

## Rabbit osteoarthritis

[Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model](https://pubmed.ncbi.nlm.nih.gov/26275694/) supplies the cartilage result discussed throughout the site. Its outcome language is the essential starting point for the [cartilage essay](/cartilage-scores).

## Earlier fat-metabolism experiments

[Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone](https://pubmed.ncbi.nlm.nih.gov/8358331/) separates fat formation from glycerol release in the rat-tissue assay. [Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone](https://pubmed.ncbi.nlm.nih.gov/11146367/) develops the fragment's metabolic characterisation.

The more demanding mechanistic test is [The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice](https://pubmed.ncbi.nlm.nih.gov/11713213/): the altered receptor system separates acute and chronic responses.

## Human tolerability

[Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans](https://www.jofem.org/index.php/jofem/article/view/157/194) concerns the oral trial programme in obese adults.

[Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance](https://pubmed.ncbi.nlm.nih.gov/41966639/) brings a broader safety assessment to the musculoskeletal discussion. That broader caution and the oral exposure report have separate places in the [human record](/human-record).

## References

[1] Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model https://pubmed.ncbi.nlm.nih.gov/26275694/
[2] Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans https://www.jofem.org/index.php/jofem/article/view/157/194
[4] Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone https://pubmed.ncbi.nlm.nih.gov/8358331/
[5] The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice https://pubmed.ncbi.nlm.nih.gov/11713213/
[6] Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone https://pubmed.ncbi.nlm.nih.gov/11146367/
[8] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://pubmed.ncbi.nlm.nih.gov/41966639/

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Renew Regenerative Med is my cartilage scorebook about published research, not a medical business, and none of these arguments constitutes medical advice.